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Medical Tecnologies

Medical Technologies

Medical Controlled Release Devices (M-CRDs)


Gurman, P., K. Clayton, O. R. Miranda, Y. Rosen, N. M. Elman, “Clinical Applications for Controlled Drug Delivery Devices based on MEMS,” Proceedings of Mayo Clinic, Vol. 90, Issue 1, 93-108, 2015.


Curi, S. D. Veysset, R. Cantor Balan, S. Kooi, K. A. Nelson, N. M. Elman, S. D’hers, “Rupture Mechanism For Thin Shells Based On Ultrasound Activation For Subcutaneous Controlled Drug Delivery Systems.” 11th World Congress on Computational Mechanics, March 2014.


M. Pourriahi, P. Gurman, J. Daich, P. Cynamon, A. Richler, N. M. Elman, Y. Rosen, “The use of micro-electro mechanical systems in vascular monitoring: implications for clinical use,” Expert Review of Medical Devices Vol. 13, Issue 9, 2016


A.H. Chi, K. Clayton, T.J. Burrow, R. Lewis, D. Luciano, F. Alexis, S D'hers, N. M. Elman “Intelligent Drug-Delivery Devices Based on Micro and Nano-Technologies,” Therapeutic Delivery 01/2013; 4(1):77-94. 2013.


Rosen, Y., P. Gurman, N. M. Elman, E. Laor. “The Haitian Earthquake Relief Experience of a Rapidly Deployed, Small Tent Hospital: The Need for Its Transformation with Hand-Held Nano/Micro Technologies,” Letter, Prehospital and Disaster Medicine 27 (03), 303-304. 2012.


Adams, J.M., R, Failano, A. Bordetsky, N. Elman, E. Bourakov, A.A. Adams. “Setting the Stage for the Future of Care Delivery: Civilian Implications for Emerging Battlefield Care Technologies,” Voice of Nursing Leadership, 9(6) 8-10. 2011.


Ho Duc, H-L., N. M. Elman, AM Hayward, D.J. Rabideau, M.J. Cima. “In Vivo rapid delivery of vasopressin from an implantable drug delivery micro-electro-mechanical device,” International Journal of Drug Delivery 3 (2), 219-227. 2010.


Elman, N. M., B. C. Masi, M. J. Cima, R. Langer. "Electro-thermally induced structural failure actuator (ETISFA) for implantable controlled drug delivery devices based on Micro-Electro-Mechanical-Systems." Lab on a Chip 10(20): 2796-2804. 2010.


Elman, N. M. and U. M. Upadhyay. "Medical Applications of Implantable Drug Delivery Microdevices Based on MEMS (Micro-Electro-Mechanical-Systems)." Current Pharmaceutical Biotechnology 11(4): 398-403. 2010.


Elman, N. M. "The Next Generation of Drug Delivery Systems and Diagnostics Based on Micro-Electro-Mechanical-Systems (MEMS) and Nanotechnology." Current Pharmaceutical Biotechnology 11(4): 318-319. 2010.


Elman, N. M., Y. Patta, et al. "The Next Generation of Drug-Delivery Microdevices." Clinical Pharmacology & Therapeutics 85(5): 544-547. 2009.


Elman, N. M., H. L. H. Duc, M. J. Cima. (2009). "An implantable MEMS drug delivery device for rapid delivery in ambulatory emergency care." Biomedical Microdevices 11(3): 625-631.


Elman, N.M., Y Patta, HLH Duc, K Daniel, B Masi, A Scott, M J. Cima "Micro- and Nano-Electro Mechanical (MEMS and NEMS)-based Technologies for Implanted Biomedical Devices." IEEE International Electron Devices Meeting 2008, Technical Digest: 327-330. 2008.


Elman, N. M., H-L. Hoc Duc, M. J. Cima “Drug Delivery Device based on MEMS Technology,” in National U.S. Army Research Proceedings, August 2008 


Elman, N. M., H-L., Ho Duc, and M. J. Cima. "A Micro-Implant based on MEMS (Micro-Electro-Mechanical-Sysems) Technology for Treatment of Hemorrhagic Shock in Ambulatory Settings." Nanotech Proceedings, 2008


Elman, N. M., H-L. Hoc Duc, M. J. Cima. “Implantable Drug Delivery System based on MEMS Technology,” in NanoTech Proceedings, 7(2), 402-404. 2007.

Controlled Release Nanoparticles (CRNs)


S Boyaji, J Merkow, NM Elman, AD Kaye, RJ Yong. "The Role of Cannabidiol (CBD) in Chronic Pain Management: An Assessment of Current Evidence." Current Pain and Headache Reports. 2020 Jan;24(2):4.


Rosen, Y., U. M. Upadhyay, N. M. Elman. “Pharmacogenomics-based RNA Interference Nanodelivery: Focus on Solid Malignant Tumors,” Expert Opinion, 9 (7), 755-766. 2012.


Elman, N. M., K. Daniel, F. Jalali-Yazdi, M. J. Cima. “High Flux Nano-Filters,” in Nanotech Proceedings, May 2009


Rosen, Y. and N. M. Elman. "Carbon nanotubes in drug delivery: focus on infectious diseases." Expert Opinion on Drug Delivery 6(5): 517-530, 2009.


G. Y. Kim, K. D. Daniel, C. C. Vassiliou, N. M. Elman, L. Josephson, M. J. Cima, “Nanoparticle-based Cancer Bio-marker Sensor,” Nanotech Proceedings, 2007(2) 218-220


Rapid Reconstitution Packages (RRPs)


S. D’hers, A. N. Abad Vazquez, P. Gurman, NM. Elman. “Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon,” Drug Delivery and Translational Research, 9(3):735-736, 2019. 


Chi A, Curi S, Clayton K, Luciano D, Klauber K, Alexander-Katz A, D'hers, S. Elman, NM. Rapid Reconstitution Packages (RRPs) implemented by integration of computational fluid dynamics (CFD) and 3D printed microfluidics. Drug Delivery and Translational Research. 2014;4(4):320–333.


P. Gurman, A. H. Chi, T. T. Hood, M. Reina, Y. Rosen, S. D’hers, N. M. Elman, “Prefilled Devices for Parenteral Applications” Expert Reviews on Medical Devices, 11:2, 205-223, 2014.


Gurman P, Miranda OR, Nathan A, Washington C, Rosen Y, Elman NM. "Recombinant Tissue Plasminogen Activators (rtPA): A Review." Clin Pharmacol Ther. 2015;97:274–85


Vector Control

Vector Control

Siegel, E.L.; Xu, G.; Li, A.Y.; Pearson, P.; D’hers, S.; Elman, N.; Mather, T.N.; Rich, S.M. Ixodes scapularis Is the Most Susceptible of the Three Canonical Human-Biting Tick Species of North America to Repellent and Acaricidal Effects of the Natural Sesquiterpene, (+)-Nootkatone. Insects 2024, 15, 8.

Flores-Mendoza C, López-Sifuentes, VM, Vásquez GM, Stoops CA, Fisher, ML, Bernier UR, Perry M, Mollica J,  Coltzau, DA, Gurman P, D’hers S; Elman, NM, "Field Evaluation of Novel Spatial Repellent Controlled Release Devices (CRDs) against Mosquitoes in an Outdoor Setting in the Northern Peruvian Amazon," Trop. Med. Infect. Dis. 2022, 7, 372.

Siegel EL, Olivera M, Roig EM, Perry M, Li AY, D’hers S, Elman NM, Rich SM. "Spatial repellents transfluthrin and metofluthrin affect the behavior of Dermacentor variabilis, Amblyomma americanum, and Ixodes scapularis in an in vitro vertical climb assay," PLOS ONE 2022; 17(11): e0269150.

Bernier UR, Kline DL, Vazquez-Abad A, Perry M, Cohnstaedt LW, Gurman P, D'hers, S, Elman, NM, "A Combined Experimental-Computational Approach for Spatial Protection Efficacy Assessment of Controlled Release Devices against Mosquitoes (Anopheles)," PLoS Negl Trop Dis. 2018;13(3):e0007188


Stevenson JC, Simubali L, Mudenda T, Cardol E, Bernier UR, Abad Vazquez A, Thuma PE, Norris DE, Perry M, Kline DL, Cohnstaedt LW, Gurman P, D’hers S, Elman NM. "Controlled release spatial repellent devices (CRDs) as novel tools against malaria transmission: a semi-field study in Macha, Zambia," Malaria Journal, 2018-17:437.


Bernier U, Gurman P, Clark G, Elman NM, “The Use of Microdispensers with Spatial Repellents for Personal Protection Against Mosquito Biting,” Journal of Medical Entomology, 53 (2), 470-472, 2016.


U. Bernier, P. Gurman, N. M. Elman, “Functional Micro-Dispensers based on Micro-Electro-Mechanical-Systems (MEMS) Integrated with Fabrics as Functional Materials to Protect Humans from Mosquitoes,” Journal of Controlled Release, 220 (Part A), 1-4, 2015. 

Agriculture and Vector Control

Agriculture and Vector Control

UAV-Based Tactical Pest Management Systems  (TPMS)


L. Z. Bright, S. Curi, M. Handley, D. Samson, I. Chien, L. A. Brownworth, P. Gurman, S. D’hers, N. M. Elman, “Analytical Models Integrated with Satellite Images for Optimized Pest Management,” Journal of Precision Agriculture, 17 (5), 628-636, 2016.


Controlled Release Particles (CRPs)


W. L. Meyer, P. Gurman, L. Stelinski, N. M. Elman, “Functional Nanodispensers for In Vivo Delivery of Pesticides against Psyllids,” Green Chemistry, 17 (8), 4173-4177. 2015.


Elman, N.M., K. Daniel, F. Jalali-Yazdi, M. J. Cima. Super permeable nano-channel membranes defined with laser interferometric lithography. Microfluidics and Nanofluidics 8 (4), 557-563. 2010.


Whole Cell Sensors (WCS) and Biosensors


Shacham-Diamand, Y., S. Belkin, T. Elad, S. Melamed, A. Biran, S. Yagur-Krull, R. Almog, R. Daniel, A. Rabner, S. Vernick, N. M. Elman, R. Popovtser. "Optical and Electrical Interfacing Technologies for Living Cell Bio-Chips." Current Pharmaceutical Biotechnology 11(4): 376-383. 2010.


Elman, N. M., H. Ben-Yoav, M. Sternheim, R. Rosen, S. Krylov, Y. Shacham-Diamand. "Towards toxicity detection using a lab-on-chip based on the integration of MOEMS and whole-cell sensors." Biosensors & Bioelectronics 23(11): 1631-1636. 2008.


Elman, N. M., S. Krylov, M. Sternheim, Y. Shacham-Diamand. "Multiple aspect-ratio structural integration in single crystal silicon (MASIS) for fabrication of transmissive MOEMS modulators." Microsystem Technologies 14 (2), 287-293. 2008


Elman, N. M., S. Krylov, M. Sternheim, Y., Shacham-Diamand. "Bioluminescence detection using a novel MEMS modulation technique." IEEE Photonics Technology Letters 18 (19), 2011-2013. 2006.


Elman, N. M., S. Krylov, M. Sternheim, Y., Shacham-Diamand. "Integrated heterodyne MOEMS for detection of low intensity signals," MOEMS Display, Imaging, and Miniaturized Microsystems IV 6114: D1140-D1140.240. 2006.


Rosen Y, Elman NM. "Biomaterial Science. An Integrated Clinical and Engineering Approach." CRC-Press, New York, 2012.

Rosen, Y, Gurman, P., Elman, NM. "Drug Delivery. An Integrated Clinical and Engineering Approach (1st ed.)" CRC Press, Boca Raton, 2017.

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