M-CRDs are the future of drug delivery. M-CRDs are advanced miniaturized controlled drug delivery system that can be integrated with electronics to program pharmacokinetic profiles. M-CRDs can be integrated with patches, or implanted as minimally invasive devices. M-CRDs can also can be integrated with sensors for close-loop applications.
Application Examples: hemorrhage, epilepsy, diabetes, hypoglycemia.
Examples of Delivery Modalities: transcutaneous, transdermal, intramuscular, intraosseous, intranasal, intraperitoneal.
Examples of APIs: vasopressin, Factor VII, insulin, glucagon.
MEMS-Based Controlled Drug Delivery Devices (M-CRDs)
Patch Controlled Drug Delivery Devices (P-CRDs)
P-CRDs represent the next generation of microneedle-based patches for painless controlled drug delivery. P-CRDs can be integrated with multiple APIs as part of bandage, or large patch. The microneedles are bio-absorbable and can be tailored for long term release.
Application Examples: pain, diabetes, endocrine disorders, bacterial infections, infectious diseases.
Examples of Delivery Modalities: transcutaneous, transdermal.
Examples of APIs: CBD, antibiotics, HGH, vaccines.
Rapid Reconstitution Packages (RRPs)
RRPs are advanced reconstitution and delivery systems for critical applications that use low solubility APIs and large payload applications. RRPs can be seamlessly integrated with standard syringes, or used as stand-alone injectors. RRPs make use of microfluidics to perform optimal on-spot reconstitution and delivery of multiple AIs. RRPs can store drugs in lyophilized form for long term storage and reconstitute on demand without the need of shaking.
Application Examples: stroke, hypoglycemia, bacterial infections, infectious diseases.
Examples of Delivery Modalities: transcutaneous, transdermal, intramuscular, intravenous, intraperitoneal.
Examples of APIs: tPA, glucagon, antibiotics, vaccines.
Controlled Release Nanoparticles (CRNs)
CRNs represent the next generation of pharmacological therapies based on nanoparticles delivery. Nanoparticles could be polymeric or liposomal for controlled release of APIs. CRNs can be used with multiple APIs and could be used for a number of applications that require tuning of pharmacokinetics. CRNs can be stored drugs in lyophilized form for long term storage. CNRs can also be functionalized to target specific areas
Application Examples: pain, bacterial infections, infectious diseases.
Examples of Delivery Modalities: intravenous, oral, local delivery.
Examples of APIs: CBD, antiobiotics, vaccines.
Whole-Cell Sensors (WCS)
WCS represent the next generation of testing based on genetically engineered cells that act as sensors to measure a targeted molecule, including RNA. Genetically engineered cells, e.g. bacteria or yeast, can be tailored to identify and express detection for a number application that require small concentration detection with a very rapid response. WCS represent an alternative to traditional analytical chemistry tools. WCS can be integrated with electronics for fast readout and can also be lyophilized for long term storage.
Application Examples: detection of toxins, pathogens and small molecules in liquid small molecules.
Examples of Detection Modalities: portable applications, high throughput applications.
Examples of Targeted Detection: mRNA, viruses, toxins.